Pharma 4.0
With pressure to meet increasing production demands, process analytical technologies (PAT) enable you to improve operational efficiencies and lean out processes. RTRT enables process understanding, process control, efficiency gains, and optimization to drive efficiency, all while ensuring precise, accurate, and robust data that aligns with data integrity requirements – ultimately lending itself to the Pharma 4.0 era.
Portfolio
Resources
Products
Sievers M500 Online TOC Analyzers
Save time, reduce costs and meet regulations with accurate, stable online UPW monitoringSievers DataShare Elite Software
Multiple Instruments. One Database. World-wide Access.Developing a successful plan for RTRT
There are different ways in which online TOC data can be used—process monitoring, process control, and process understanding. RTRT is validated to provide process monitoring, process control, and process understanding to release water into production in real-time. The process to be able to use an online instrument for the release of water into production can be broken down into phases.
RTT Phases and Elements
- Phase 1: Organize and Define
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- Project scope and principles
- Phase 2: Risk Assessment
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- Evaluate current and future states
- Technology choice
- Placement on water system
- Phase 3: Implementation
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- Validation
- Method transfer
- Measurement System Equivalency
- Comparability study
- Phase 4: Reporting and Data Handling
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- Data handling and reporting
- Alert and action limits
- Phase 5: Maintenance
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- Redundancy
- Preventative maintenance
- Investigation procedures for OOS