Meet pharmaceutical regulations and validate cleaning processes with quantitative TOC analysis

Total organic carbon (TOC) analysis is essential for monitoring pharmaceutical Purified Water (PW) and Water for Injection (WFI), where water quality directly impacts product safety and is a requirement for regulatory compliance. As a Process Analytical Technology (PAT), continuous real-time TOC monitoring serves as an early warning system for potential contamination or system issues, enabling immediate process control decisions and optimizing manufacturing efficiency.

Beyond water system monitoring, TOC is a proven marker for detecting organic residues during cleaning validation. Compared to other analytical methods used to validate cleaning processes, TOC provides a comprehensive analysis of contamination that can compromise product quality and lead to batch failures.

Using TOC for cleaning validation streamlines method development while providing more comprehensive analysis than other tools. It detects all organic compounds - including APIs, degradants, cleaning agents, and excipients - offering greater versatility than compound-specific methods like HPLC. With at-line and online cleaning validation capabilities, you can reduce equipment release time and minimize error risks.

Safeguard equipment, optimize water treatment, and ensure utility water is clean with accurate TOC process monitoring

Total organic carbon (TOC) analysis plays a vital role across industrial processes, ensuring optimization and control of feedwater, steam generation, boiler protection, and wastewater treatment.

From protecting valuable equipment assets to ensuring process efficiency and compliant effluent discharge, TOC monitoring provides critical data for operational decision-making and process optimization. This is especially valuable in wastewater process monitoring, where TOC analysis produces rapid and accurate data in just minutes, unlike traditional BOD and COD tests which take days or hours to complete.

Wastewater monitoring: 

• Influent control
  • Track feedwater
  • Monitor organic load fluctuations 
• Treatment process
  • Improve decisions using process TOC data
  • Optimize anaerobic digestion with steady feed
  • Manage equalization tanks
• Discharge compliance
  • Effluent quality monitoring and regulatory compliance
  • Stormwater runoff control 
• Accurate TOC results within minutes, in contrast to BOD and COD tests

Utility water monitoring: 

• Protect boilers and prevent costly equipment failures and shutdowns
• Monitor condensate return quality
• Detect leaks and process upsets quickly

Cleaning verification:

• CIP (clean-in-place) monitoring
• Optimize cleaning processes and reduce water consumption
• Meet post-cleaning targets

Source water monitoring: 

• Check raw water water quality 
• Optimize treatment 
• Protect downstream equipment and processes

Learn more about the Sievers InnovOx SCWO technology