Veolia Water Technologies & Solutions

Sievers 500 RL On-Line TOC Analyzer

Reliable, accurate performance for online TOC monitoring and real-time testing

Used extensively in the pharmaceutical industry, the Sievers 500 RL On-Line TOC Analyzer offers unmatched stability and performance. It provides online TOC analysis for compliance with USP <643> and other global pharmacopeia and can be provided with the critical protocols required for real-time testing (RTT) process validation. Specific features are offered for pharmaceutical applications, such as automated validation and system suitability testing, the ability to measure USP <645> conductivity, and compliance with 21 CFR Part 11. The 500 RL uses the most robust analytical technology available and is easy to implement and maintain.

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Learn about the NEW Sievers M500/e TOC Analyzers

Pharmaceutical Industry Compliance

The Sievers 500 RL is engineered to meet stringent global regulatory requirements in the pharmaceutical industry, including USP <643>, EP 2.2.44 Total Organic Carbon, IP 2.4.30, CP Appendix VIII R, and JP16 2.59 monographs for Purified Water and Water for Injection. Sievers DataGuard software facilitates compliance with 21 CFR Part 11.

Features & Benefits

M500 Online Features & Benefits

Accuracy. Efficiency. Integrity.

  • 150% faster analysis time
  • Advanced communications: Ethernet, WiFi, 4-20mA, Modbus, and Serial connectivity
  • 10-inch color touchscreen
  • Super iOS 4-port sampler automates grab samples to improve productivity
  • Simultaneous TOC & conductivity measurement
  • Automated system suitability calibration, & validation
  • 50% faster validation protocols
  • IP55 & full IP connections
  • Same footprint as 500 RL for easy upgrades


M500 Online Specifications

Total Organic Carbon

Linear Range 0.03 to 2,500 ppb as TOC
Accuracy ± 5% of measurement; ±0.1 ppb
Precision ± 1% of measurement; ±0.3 ppb
pH Range 5.5 to 8.0 in order to meet accuracy specification
Analysis Modes On-line, on-line averaged, on-line timed, Grab
Analysis Time1,2 3 minutes for continuous online measurements
Ozone Compatibility 50 ppb Ocontinuous; 200 ppb 03 for 2 hours daily
External Flow Rate Minimum 50 mL/min
Sample Temperature 1–95 °C (34–203 °F) (withstands short-term exposure)
Sample Pressure Up to 100 psig
Interferences Insensitive to organic heteroatoms
Calibration Stability Typically stable for 12 months
Display Readout 3 significant digits


Raw Conductivity Range 0.01 to 800 µS/cm
Conductivity Accuracy 0.005 µS/cm or 1%, whichever is greater
Conductivity Precision <1.0% RSD


Power Requirements 100–240 VAC, 70 W, 50/60 Hz
Fuses No user-replaceable fuses
Normal Operating Environment Intended for indoor use only
Ambient Temperature 5–40°C (41–104°F)
Maximum Relative Humidity Up to 95%, noncondensing
Maximum Altitude 3,000 m (9,843 ft)
Inputs Two isolated binary inputs
Outputs Serial (RS-232), one USB, three 40-20 mA, four alarms, one Ethernet
Installation/Overvoltage II (protects against transients present in Category II power)
Safety Certifications

CE, ETL listed. Conforms to UL Std. 61010-1. Certified to CSA 22.2 No. 61010-1.

Pollution Degree 2 (normally only non-conductive pollution)
Display Backlit 10.1", 1280x800, touchscreen display
Size H: 43.4 cm (17.1 in); W: 55.9 cm (22.0 in); D: 28.7 cm (11.3 in)
Weight 16.3 kg (36 lb)
IP Rating IP 55
Optional Wi-Fi 802.11ac/a/b/g/n Dual-band 2.4/5 GHz
Industrial Communications Protocol Modbus TCP/IP


1Time to first measurement is 10 minutes

2Base model analysis time is six minutes for continuous online measurement

Learn how the 500 RL makes online TOC analysis in pharma easier